Nonanimal Skin Test in Development at Lebrun Labs LLC

News

2022

Upcoming Presentation: Society of Toxicology (SOT), 2022 Conference
March 2022

Classification of agrochemicals for eye irritancy potential using the IVD EIT (In Vitro Depth of Injury Eye Irritation Test) 
Stewart J. Lebrun, Linda Nguyen, Sara Chavez, and James V. Jester
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Journal Publication in Toxicology in Vitro
January 2022
Ascorbic acid specifically reduces the misclassification of nonirritating reactive chemicals in the OptiSafe™ macromolecular eye irritation test
Stewart Lebrun, Sara Chavez, Roxanne Chan, Linda Nguyen, James V. Jester
 


2021

Journal Publication in Toxicology in Vitro
June 2021
Modeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe)
Stewart J.Lebrun, Sara Chavez, Roxanne Chan, Linda Nguyen, James V. Jester

Presentation: Society of Toxicology (SOT), 2021 Virtual Conference
March 12–26, 2021

  1. Further Optimization of the OptiSafeTM Nonanimal Test Method
    S. Chavez, S. Lebrun

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  2. Repeatability of a Depth of Injury Test Method for the Classification of Eye Irritants 
    Priya Mistry, James V. Jester, Debby Le, Stewart Lebrun

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2020

Journal Publication in Toxicology in Vitro
December 2020
Same chemical comparison of nonanimal eye irritation test methods: Bovine corneal opacity and permeability, EpiOcular™, isolated chicken eye, ocular Irritection®, OptiSafe™, and short time exposure
Stewart Lebrun, Linda Nguyen, Sara Chavez, Roxanne Chan, Debby Le, Minh Nguyen, James V.Jester  

Journal Publication in Cutaneous and Ocular Toxicology
September 2020
Validation of the OptiSafe™ eye irritation test
Neepa Choksi, Stewart Lebrun, Minh Nguyen, Amber Daniel, George DeGeorge, Jamin Willoughby, Adrienne Layton, Donnie Lowther, Jill Merrill, Joanna Matheson, João Barroso, Krystle Yozzo, Warren Casey, David Allen 

Virtual Presentation by Sara Chavez of Lebrun Labs LLC: Summer School on Innovative Approaches in Science hosted by The Physicians Committee for Responsible Medicine, the European Commission Joint Research Centre, and the Johns Hopkins University Center for Alternatives to Animal Testing
June 2020
Improved Version of the OptiSafe™ Test with High Specificity
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Lebrun Labs LLC Awarded SBIR phase I Grant to Develop a Nonanimal Test for Reversible Ocular Irritants.
June 2020 
GRANT NUMBER: R43ES031881
GRANT TITLE: IVD EIT: A Nonanimal Kit and Service for the Detection of Reversible Ocular Irritants
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research was supported by the NIEHS of the National Institutes of Health under Award Number R43ES031881. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Presentation: Society of Toxicology (SOT) 2020, Virtual Conference
March 2020

  1. An Improved Version of the OptiSafe Test with High Specificity 
    S. Chavez, S. Lebrun

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2019

Journal Publication in Toxicology in Vitro
December 2019
An in vitro depth of injury prediction model for a histopathologic classification of EPA and GHS eye irritants
Stewart Lebrun, Yilu Xie, Sara Chavez, Roxanne Chan, James V. Jester

Presentations: Society of Toxicology (SOT) 2019, Baltimore, Maryland
March 2019

  1. Prevalidation of the OptiSafe Ocular Irritation Assay for the Detection of Ocular Corrosives 
    S Lebrun, N Choksi, A Daniel, D Allen, W Casey
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  2. Classification of EPA Ocular Irritants and Non-Irritants by the OptiSafeTM Test Method of Mixtures

    P. Vij, S. Lebrun, G. DeGeorge


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2018

Lebrun Labs LLC Awarded SBIR phase II Grant to Further Develop and commercialize the OptiSafe Nonanimal eye irritation test.
December  2018 
GRANT NUMBER: R44ES025501
GRANT TITLE: Non-Animal Test Method to Determine the Ocular Safety of Consumer Products and Chemicals: Phase II
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research reported in this publication was supported by the NIEHS of the National Institutes of Health under Award Number R44ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Lebrun Labs LLC Awarded Patent on the OptiSafe Test Method
August 7, 2018
Biochemistry based ocular toxicity assay; United States Patent US10041922

Society of Toxicology (SOT) 2018, San Antonio, Texas
March 2018
Performance of the OptiSafe Ocular Irritation Assay in a Three-Laboratory Validation Study
N Choksi, A Daniel, S Lebrun, M Nguyen, G DeGeorge, JA Willoughby, Sr., W Casey, D Allen
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2015

Lebrun Labs LLC Awarded SBIR phase I Grant to Develop a Nonanimal Test for Ocular Nonirritants.
March 2015 
GRANT NUMBER: R43ES025501
GRANT TITLE: Non-Animal Test Method To Determine The Ocular Safety Of Consumer Products and Chemicals
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research was supported by the NIEHS of the National Institutes of Health under Award Number R43ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.