2024
Lebrun Labs LLC Awarded SBIR Fast-Track Grant to Develop Skin Corrosion Test.
April 2024
GRANT NUMBER: 1R44ES036065
GRANT TITLE: An In Chemico Test to Identify Dermal Corrosive
https://reporter.nih.gov/search/tAOLlz36e0KpGm4KoDcEPA/project-details/10822593
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research was supported by the NIEHS of the National Institutes of Health under Award Number R44ES031881. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
OptiSafe Eye Irritation TestTM paper awarded the OTSS Annual SOT “Paper of the Year” Award
March 2024
Further optimisation of a macromolecular ocular irritation test (OptiSafeTM)
2023
The OptiSafe Eye Irritation TestTM has been added to OECD draft TG 496
December 2023
https://www.oecd.org/env/ehs/testing/Draft-updated-test-guideline-496-macromolecular-test-methods-eye-hazard-potential.pdf
Lebrun Labs LLC Awarded NEI/CounterAct R21 Research Grant to Develop Countermeasures Against Chemical Threats
June 2023
GRANT NUMBER: R21EY033713
GRANT TITLE: Antioxidant Eye Wash Formulations to Counter Ocular Chemical Threats
https://reporter.nih.gov/search/4cF6aAPPKkq4VYrj2ejV3w/project-details/10631664
Award Info: Research reported in this publication was supported by the National Eye Institute of the National Institutes of Health under Award Number R21EY033713. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Lebrun Labs LLC Awarded SBIR phase II Grant to Further Develop the IVD EIT.
May 2023
GRANT NUMBER: R44ES031881
GRANT TITLE: IVD EIT: A Nonanimal Kit and Service for the Detection of Ocular Irritants
https://reporter.nih.gov/search/4cF6aAPPKkq4VYrj2ejV3w/project-details/10699287
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research was supported by the NIEHS of the National Institutes of Health under Award Number R44ES031881. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
OptiSafe paper recognized as one of the "Papers of the Month" by the NIEHS Environmental Factor Newsletter
January 2023
Novel Method can reduce the use of animals in eye safety tests
Journal Publication in Toxicology in Vitro
February 2023
Expansion of the application domain of a macromolecular ocular irritation test (OptiSafe™)
Stewart Lebrun, Sara Chavez, Linda Nguyen, Roxanne Chan
Journal Publication in Cutaneous and Ocular Toxicology
January 2023
Further Optimisation of a macromolecular ocular iritation test (OptiSafeTM)
Stewart Lebrun, Sara Chavez, Linda Nguyen, Roxanne Chan
2022
Lebrun Labs LLC Awarded SB1 Grant to Further Develop and commercialize the OptiSafe EIT.
September 2022
GRANT NUMBER: SB1ES025501
GRANT TITLE: Non-Animal Test Method to Determine the Ocular Safety of Consumer Products and Chemicals: Commercialization
https://reporter.nih.gov/search/4cF6aAPPKkq4VYrj2ejV3w/project-details/10696247
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research reported in this publication was supported by the NIEHS of the National Institutes of Health under Award Number SB1ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Presentation: Society of Toxicology (SOT), 2022 Conference
March 2022
Classification of agrochemicals for eye irritancy potential using the IVD EIT (In Vitro Depth of Injury Eye Irritation Test)
Stewart J. Lebrun, Linda Nguyen, Sara Chavez, and James V. Jester. Read More...
Journal Publication in Toxicology in Vitro
January 2022
Ascorbic acid specifically reduces the misclassification of nonirritating reactive chemicals in the OptiSafe™ macromolecular eye irritation test
Stewart Lebrun, Sara Chavez, Roxanne Chan, Linda Nguyen, James V. Jester
2021
Journal Publication in Toxicology in Vitro
June 2021
Modeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe EIT)
Stewart J.Lebrun, Sara Chavez, Roxanne Chan, Linda Nguyen, James V. Jester
Presentation: Society of Toxicology (SOT), 2021 Virtual Conference
March 12–26, 2021
2020
Journal Publication in Toxicology in Vitro
December 2020
Same chemical comparison of nonanimal eye irritation test methods: Bovine corneal opacity and permeability, EpiOcular™, isolated chicken eye, ocular Irritection®, OptiSafe EIT™, and short time exposure
Stewart Lebrun, Linda Nguyen, Sara Chavez, Roxanne Chan, Debby Le, Minh Nguyen, James V.Jester
Journal Publication in Cutaneous and Ocular Toxicology
September 2020
Validation of the OptiSafe eye irritation test
Neepa Choksi, Stewart Lebrun, Minh Nguyen, Amber Daniel, George DeGeorge, Jamin Willoughby, Adrienne Layton, Donnie Lowther, Jill Merrill, Joanna Matheson, João Barroso, Krystle Yozzo, Warren Casey, David Allen
Virtual Presentation by Sara Chavez of Lebrun Labs LLC: Summer School on Innovative Approaches in Science hosted by The Physicians Committee for Responsible Medicine, the European Commission Joint Research Centre, and the Johns Hopkins University Center for Alternatives to Animal Testing
June 2020
Improved Version of the OptiSafe™ Test with High Specificity
Read More...
Lebrun Labs LLC Awarded SBIR phase I Grant to Develop a Nonanimal Test for Reversible Ocular Irritants.
June 2020
GRANT NUMBER: R43ES031881
GRANT TITLE: IVD EIT: A Nonanimal Kit and Service for the Detection of Reversible Ocular Irritants
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research was supported by the NIEHS of the National Institutes of Health under Award Number R43ES031881. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Presentation: Society of Toxicology (SOT) 2020, Virtual Conference
March 2020
2019
Journal Publication in Toxicology in Vitro
December 2019
An in vitro depth of injury prediction model for a histopathologic classification of EPA and GHS eye irritants
Stewart Lebrun, Yilu Xie, Sara Chavez, Roxanne Chan, James V. Jester
Presentations: Society of Toxicology (SOT) 2019, Baltimore, Maryland
March 2019
P. Vij, S. Lebrun, G. DeGeorge
2018
Lebrun Labs LLC Awarded SBIR phase II Grant to Further Develop and commercialize the OptiSafe Nonanimal eye irritation test.
December 2018
GRANT NUMBER: R44ES025501
GRANT TITLE: Non-Animal Test Method to Determine the Ocular Safety of Consumer Products and Chemicals: Phase II
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research reported in this publication was supported by the NIEHS of the National Institutes of Health under Award Number R44ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Lebrun Labs LLC Awarded Patent on the OptiSafe Test Method
August 7, 2018
Biochemistry based ocular toxicity assay; United States Patent US10041922
Society of Toxicology (SOT) 2018, San Antonio, Texas
March 2018
Performance of the OptiSafe Ocular Irritation Assay in a Three-Laboratory Validation Study
N Choksi, A Daniel, S Lebrun, M Nguyen, G DeGeorge, JA Willoughby, Sr., W Casey, D Allen
Read More...
2015
Lebrun Labs LLC Awarded SBIR phase I Grant to Develop a Nonanimal Test for Ocular Nonirritants.
March 2015
GRANT NUMBER: R43ES025501
GRANT TITLE: Non-Animal Test Method To Determine The Ocular Safety Of Consumer Products and Chemicals
Award Info: National Institute of Environmental Health Sciences (NIEHS) Small Business Innovative Research Grant. Research was supported by the NIEHS of the National Institutes of Health under Award Number R43ES025501. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.