Toxicology In Vitro, 2019 Dec
Read MoreOptiSafeTM is a shelf-stable, nonanimal test method to determine whether a chemical or mixture of chemicals is an ocular irritant.
Read MoreThe purpose of this study is to evaluate variability in the newly developed Globally Harmonized System (GHS) prediction model for classifying ocular irritant materials based on depth of injury (DoI) measurements. Previously, 16 different materials were tested, representing all classes of toxicity, a
Read MoreSociety of Toxicology Annual Meeting: An Improved Version of the OptiSafe Test with High Specificity.Most chemical and product safety testing for eye irritation and toxicity has historically used the Draize live rabbit eye test, in which the eyes of unanesthetized New Zealand White rabbits are expos
Read MoreDevelopment and Optimization of Nonanimal Alternative Test Methods. In vitro approach for the detection of GHS Classified Ocular Irritants. Routine testing of cosmetic and personal care products to assess the safety for consumer use. Co-Inventor of Methods and Reagents to Improve the Specificity, Se
Read MoreOptiSafeTM is a novel, shelf stable, test tube-based assay that can discriminate ocular irritants/corrosives from nonirritants and does not use animal tissues or cells. It can determine whether an unknown substance is an ocular nonirritant by measuring and comparing chemical models for th
Read MoreThe EPA eye irritation classification system is routinely used to categorize ocular toxicity. The EPA system classifies chemicals that damage the eye after 24 hours (Category III, II, or I) and those that do not cause damage (Category IV). This latter EPA classification is aligned with the standard
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