Resources

Useful Documents

 

Lebrun Labs LLC Abstracts

 

2021

Society of Toxicology Annual Meeting: Repeatability of a Depth of Injury Test Method for the Classification of Eye Irritants.
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Society of Toxicology Annual Meeting: Further Optimization of the OptiSafe™ Nonanimal Test Method.
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2020

Summer School on Innovative Approaches in Science: An Improved Version of the OptiSafe Test with High Specificity.
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Society of Toxicology Annual Meeting: An Improved Version of the OptiSafe Test with High Specificity.
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2019

Society of Toxicology Annual Meeting: Classification of EPA Ocular Irritants and Non-Irritants by the OptiSafe™ Test Method of Mixtures.
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Society of Toxicology Annual Meeting: Prevalidation of the OptiSafe Ocular Irritation Assay for the Detection of Ocular Corrosives.
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Lebrun Labs LLC Publications


2022

Ascorbic acid specifically reduces the misclassification of nonirritating reactive chemicals in the OptiSafe™ macromolecular eye irritation test
 

2021

Modeling the antioxidant properties of the eye reduces the false-positive rate of a nonanimal eye irritation test (OptiSafe)
 

2020

Same-chemical comparison of nonanimal eye irritation test methods: Bovine corneal opacity and permeability, EpiOcular™, isolated chicken eye, ocular Irritection®, OptiSafe™, and short time exposure.

 

2019

An in vitro depth of injury prediction model for a histopathologic classification of EPA and GHS eye irritants.

 


OECD Documents

Nonanimal Eye Tests:

EpiOcularTM (OECD 492) Test Guideline No. 492: Reconstructed human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage

Short Time Exposure (OECD 491) Test Guideline No. 491: Short Time Exposure In Vitro Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Bovine Cornea Opacity and Permeability (OECD 437) Test Guideline No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage

Nonanimal Skin Tests:

EpiDermTM SIT (OECD 439) Test Guideline No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method

EpiDermTM SCT (OECD 431) Test Guideline No. 431: In Vitro Skin Corrosion: Reconstructed Human Epidermis (RhE) Test Method

Cytotoxicity and Mutagenicity:

3T3 Neutral Red Uptake Cytotoxicity Assay (OECD 129)  Series on Testing and Assessment No. 129: Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systemic Toxicity Tests

Mammalian Cell Gene Mutation Test (OECD 476) Test Guideline No. 476: In Vitro Mammalian Cell Gene Mutation Tests Using the Hprt and Xprt Genes

Ames Test (OECD 471) Test Guideline No. 471: Bacterial Reverse Mutation Test