Lebrun Labs Granted New Patent to Improve the IVD EITTM and other Nonanimal Eye Irritation Tests
PATENT TITLE: Formulations and Methods Related to Eye Irritation
PATENT NUMBER: US12115147B2
INVENTORS: Stewart Lebrun, Roxanne Chan, Sara Chavez
ABSTRACT: The disclosure relates to formulations and methods for the in vitro testing of ocular irritants. It was discovered that adding an antioxidant formulation to in vitro ocular irritation tests, including for example, a biochemical ocular irritation test, a reconstituted human corneal epithelium (RhCE) ocular irritation test and an excised eye depth of injury (DoI) test, substantially reduces the rate of false positives without diminishing test sensitivity, resulting in more accurately predicting ocular irritancy of test substances.